Brcapro software download8/29/2023 In our study, the BRCAPRO version 5.0 had the highest combination of sensitivity, specificity, NPV and PPV for the combined probability and for the discrimination of BRCA2 mutations. The area under the ROC (AUC) curves and its corresponding asymptotic 95% CIs were calculated as a measure of the accuracy. Sensitivity, specificity, and positive and negative predictive values (PPV, NPV) were calculated for each risk model at the 10% threshold. We evaluated the performance and clinical effectiveness of four different predictive models in a population-based series of 102 Italian MBC patients characterized for BRCA1/ 2 mutations. Indeed, the occurrence of MBC is a commonly used criterion to select families for BRCA mutation testing. Although rare, MBC deserves attention because male and female breast cancers share many characteristics, including the involvement of genetic predisposition factors such as BRCA1/ BRCA2 mutations. ![]() ![]() No study has evaluated the performance of BRCA1/2 mutations prediction models in male breast cancer (MBC) series.
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